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Weird science: Your brain creates three copies for a single memory

By Katrin Buhler and Heike Sacher, University of Basel

A new study published in Science reveals that the memory for a specific experience is stored in multiple parallel "copies." These memories are preserved for varying durations, modified to certain degrees, and sometimes deleted over time, acccording to researchers from the University of Basel in Switzerland.

The ability to turn experiences into memories allows us to learn from the past and use what we learned as a model to respond appropriately to new situations. For this reason, as the world around us changes, this memory model cannot simply be a fixed archive of the good-old days. Rather, it must be dynamic, changing over time and adapting to new circumstances to better help us predict the future and select the best course of action. How the brain could regulate a memory's dynamics was a mystery -- until multiple memory copies were discovered.

Professor Flavio Donato's research group at the Biozentrum, University of Basel, uses mouse models to investigate how memories are stored in the brain and how they change throughout life. His team has now revealed that in the hippocampus, a brain region responsible for learning from experience, a single event is stored in parallel memory copies among at least three different groups of neurons. These neurons first emerged at different stages during embryonic development.

Memory copies come and go, and change with time
First to arrive during development, the early-born neurons are responsible for the long-term persistence of a memory. In fact, even though their memory copy is initially too weak for the brain to access, it becomes stronger and stronger as time passes. Also in humans, the brain might have access to such memory only some time after its encoding.

Cross-section through the hippocampus of a mouse: Early-born neurons (magenta) create a long-persisting copy of a memory. [Credit: Image courtesy of University of Basel, Biozentrum]

 

 

In contrast, the memory copy of the same event created by the late-born neurons is very strong at the beginning but fades over time, so that if one waits long enough, such a copy becomes inaccessible to the brain. In the middle ground, among neurons emerging in between the two extremes during development, a more stable copy could be observed.

Surprisingly, which copy is used might also be linked to how easy it is to change a memory -- or to use it to create a new one. The memories stored for a short time after acquisition by the late-born neurons can be modified and rewritten. This means that remembering a situation shortly after it has happened primes the late-born neurons to become active and integrate present information within the original memory.

On the contrary, remembering the same event after a long time primes the early-born neurons to be re-activated to retrieve their copy, but the associated memory can no longer easily be modified.

"How dynamically memories are stored in the brain is proof of the brain's plasticity, which underpins its enormous memory capacity," says first author Vilde Kveim.

Flexible memories enable appropriate behavior
Donato's research team has demonstrated that the activation of specific memory copies and their timing could have significant consequences on how we remember, change, and use our memories.

"The challenge the brain faces with memory is quite impressive. On one hand, it must remember what happened in the past to help us make sense of the world we live in. On the other, it needs to adapt to changes happening all around us, and so must our memories, to help us make appropriate choices for our future," Donato says.

Persistence through dynamics is a delicate act to balance, one for which we might now have an entry point to fully understand. The researchers hope that one day, understanding what drives memories to be encoded and modified in the brain might help to soften those memories that are pathologically intrusive in our daily life -- or bring back some that we thought were lost forever.

Published September 2024

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