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Clever! Indexing plungers with chamfered pins

JW Winco has developed a new type of indexing plunger -- GN 824 -- that can independently latch into edges and grooves. This is made possible by a chamfered plunger pin. When the chamfered pin encounters a raised latching geometry, it retracts and then springs back out again once it reaches the latching point. This new indexing plunger can be ordered with axial thread for fastening and a black plastic knob for operating the indexing plunger. In a clever design, the plunger pin can be adjusted by 360 degrees to ensure that it encounters the mating surface perpendicularly. This hardware is well suited for transport frames, mechanisms, or covers that need to be locked in place quickly and securely, especially without the need for manual intervention.
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New flat quarter-turn clamping fastener

IMAO Fixtureworks has expanded its One-Touch Fastener lineup to include a new quarter-turn clamping fastener that features an innovative flat design and is ideal for clamping in limited spaces. The QCFC flat quarter-turn fastener has a recessed body that protrudes only 2 mm from the mounted surface, a knob that rests flush inside the body, visible ON and OFF markings for safety, and an audible click when fully turned to clamped or unclamped position.
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New electro-proportional hydraulics cartridge valves

Helios Technologies has expanded its electro-proportional cartridge valve offerings with new solutions (models RPEP and RPEN) from its operating company Sun Hydraulics. These valves fit into the compact T-10A cavity and are rated to a max pressure of 5,000 psi (350 bar). They have a flow capacity of 25 gpm and are fully compatible with the XMD Mobile Driver, which was co-developed with sister operating company Enovation Controls. The RPEP is well suited for industrial machines like a hydraulic press, which requires precise pressure regulation. The RPEN is well suited for mobile fan drive applications to dynamically control fan speed and ensure proper temperature regulation.
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Dual-laser metal AM system makes parts faster

Renishaw's new dual-laser RenAM 500D metal additive manufacturing machine has been designed to offer exceptional product quality and productivity for a wider range of budgets. The RenAM 500D features two 500-W lasers that can access the entire build platform, delivering superior performance when compared with single-laser systems. Additionally, the RenAM 500D Ultra, fitted with Renishaw's TEMPUS technology, allows the laser to fire while the recoater is moving, saving up to nine seconds per build layer and reducing cost per part. This also helps to deliver a production speed up to three times faster than conventional single-laser systems. Many more features.
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NEW! Aluminum Press-In Inserts for plastics

SPIROL is pleased to introduce a range of 2024 aluminum Press-In Inserts. Available in symmetrical (Series INS 50) and headed (INS 51) versions, the new aluminum Press-In Inserts line complements the existing brass line. Threaded Inserts are essential for reinforcing plastic components and provide a reusable thread within a bolted assembly. This ensures a proper seating torque and prevents the potential for plastic creep over time. These inserts are designed to be Pressed-In without heat and provide the lowest cost to install with acceptable joint performance for many applications.
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When glass or plastic can't cut it: Transparent ceramics solve critical design challenges

Complex designs are still possible when grinding and polishing Fused Silica or Sapphire. Ceramic properties such as wear, abrasion resistance, and strength of these optical materials can be a designer's dream solution when high temperatures or severe environments rule out standard optical glass or plastic. INSACO is a machine shop specializing in ultra-hard and extreme materials.
→ Contact Jackson Evans, Sales Engineer at INSACO jpe@insaco.com.
→ Learn more about INSACO materials and capabilities.

New contactless link magnetic couplings use magnetic field to transmit torque

Miki Pulley Magnetic Couplings are shaft couplings that transmit torque from one shaft to another using a magnetic field instead of a physical or mechanical connection. These Magnetic Couplings are non-contact and rely on the attraction and repulsion of magnetic poles to generate rotational power. The full product range can withstand significant misalignments and are silent, vibration-free, and do not generate thermal conduction. Design advantages include configurations that are versatile for use in various engagement angles and installations. Max transmittable torque is adjustable.
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New aero and defense PEKK-based FDM polymers from Stratasys

Stratasys has partnered with top aerospace and defense companies to develop two newly qualified materials for 3D printing. Antero 800NA is a PEKK-based FDM polymer with excellent physical and mechanical properties for demanding applications. Antero 840CN03 is a high-performance PEKK-based FDM polymer with electrostatic dissipative (ESD) properties. These new advanced industrial solution materials were rigorously qualified in collaboration with Northrop Grumman, Boeing, Blue Origin, Raytheon, Naval Air Systems Command, the National Institute for Aviation Research, United States Air Force, BAE, and Stratasys Direct Manufacturing.
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New washer tech for leak-free automotive sealing

Trelleborg Sealing Solutions has launched the Rubore^® Washer, a unique solution offering virtually leak-free sealing beneath screwheads to safeguard critical systems in vehicles, especially electric ones.
Read the full article.

EOS expands its Nickel superalloys for 3D printing

EOS, a leading supplier of manufacturing solutions for industrial 3D printing, has added two new metal additive manufacturing materials: EOS NickelAlloy IN738 and EOS NickelAlloy K500, both delivering excellent performance, part properties, and value to a variety of industries that leverage EOS Laser Powder Bed Fusion (LBPF) 3D-printing technology. The IN738 superalloy is aimed at high-strength, high-stress energy and turbomachinery applications, while the K500 superalloy is a cost-effective, corrosion-resistant option for chemical, maritime, and space industries.
Learn more.

Ruland acquires RoCom Couplings, expanding beam coupling and machined spring capabilities

Ruland Manufacturing has acquired the assets of RoCom Couplings, a Santa Maria, CA-based company specializing in beaming technology, including beam couplings, machined springs, and custom beamed components. The acquisition expands Ruland's beam coupling offerings and enhances its manufacturing capabilities to better serve customers requiring precision-engineered flexible couplings and custom machined solutions.
Learn more and see what's offered.

norelem adds 30,000 new components to its range

norelem, a global manufacturer and supplier of standard components for machinery and automation, has expanded its product range by adding 30,000 parts to its catalog. Unique in the industry, this expansion brings norelem's selection of high-quality components to over 130,000 products for design engineers and machine technicians. From sensors and clamps to plungers, levers, and measurement instruments, norelem's entire supply is available to order from its online shop with guaranteed fast and reliable delivery times.
Check out what norelem has to offer. They are new to Designfax.

Wear-resistant precision hinges from JW Winco

The precision hinges GN 7580 from JW Winco supply a pivoting movement to elements such as swing arms, spacers, and clamping plates in applications such as jig construction, automation systems, or testing systems. These wear-resistant hinges feature low radial play and adjustable axial play. They are made of black anodized and high-strength alloyed aluminum, while the bearing bushings are made of bronze. Stainless steel is used for the hardened hinge axis as well as the thrust washers and adjusting screws. An additional polyamide coating on the adjusting screws provides for thread locking.
Learn more.

Supercar of the skies: Autodesk Alias design

Learn how Hill Helicopter is using Autodesk Alias to design the innovative HX50, the "supercar of the skies." The next-gen, private copter marries high-end automotive and aero design and materials to create a futuristic flying five-seat SUV for a discriminating clientele. A neat insider look.
View the video.

CNC machining: How to avoid high costs on thin walls

Parts that are light and strong are crucial to nearly every industry. To achieve better performance without risking part failure, parts must maintain a specific wall-height-to-thickness ratio and wall-height-to-length ratio. Additionally, some geometries and supports can support thin walls to achieve a lighter component weight. Dive deeper into the cost drivers behind CNC-machined thin walls in this Xometry design-for-manufacturing article.
Read the full article.

Can an injected polymer help your tissues heal after a heart attack?

Researchers have developed a new therapy that can be injected intravenously right after a heart attack to promote healing and prevent heart failure.

The therapy both prompts the immune system to encourage tissue repair and promotes survival of heart muscle cells after a heart attack. Researchers tested the therapy in rats and showed that it is effective up to five weeks after injection.

The research team, led by bioengineers at the University of California - San Diego and chemists at Northwestern University, published their findings in the April 25 issue of the journal Advanced Materials.

"Preventing heart failure after a heart attack is still a major unmet clinical need," said Karen Christman, one of the study's corresponding authors and a professor in the Shu Chien-Gene Lay Department of Bioengineering at the UC San Diego Jacobs School of Engineering. "The goal of this therapy is to intervene very soon after someone suffers a heart attack to keep them from ultimately going into heart failure."

Side-by-side comparison of heart muscle cells with and without treatment. Damage to the cells is shown in blue. On the left, tissue has been injected with saline and the damaged area is considerably larger. On the right, the issue was treated with the PLP platform and the damaged area is significantly smaller. [Credit: Image courtesy of University of California San Diego/Northwestern University]

 

 

 

 

The therapy could have broader applications, said Nathan Gianneschi, the paper's other corresponding author and a professor in the Department of Chemistry at Northwestern.

"This therapeutic platform has tremendous potential for several diseases, including everything from macular degeneration to multiple sclerosis and kidney disease," Gianneschi said.

The platform aims to block the interaction of two key proteins that intervene in the body's response to stress and inflammation. When the protein Nrf2 is activated, cells resist the degradation brought on by inflammation. But KEAP1 binds with Nrf2 to degrade it in turn. After a heart attack, this process of degradation has to be stopped so that tissues can heal better.

The protein-like polymer, or PLP, platform is made from a polymer that mimics Nrf2. Once injected intravenously, it finds KEAP1 and binds to it, preventing it from binding to the actual Nrf2 protein and degrading it.

Researchers injected rat models after a heart attack with either the PLP platform or a saline solution. The team was blinded to which animals received the polymer or saline. After five weeks, the rodents underwent MRIs while sedated. The animals injected with the polymer showed better cardiac function and significantly more healing in their heart muscle tissue. Other tests also showed that genes that promote healing of tissues were expressed more.

Researchers describe the study as a proof of concept. Before moving on to tests in larger mammals, they want to optimize the design and dosage, and conduct further analysis.

"Proteins are the molecular machines that drive all essential cellular function, and dysregulated intracellular protein-protein interactions are the cause of many human diseases," Gianneschi said. "Existing drug modalities are either unable to penetrate cells or cannot effectively engage these large disease target domains. We are looking at these challenges through a new lens."

The therapy method was developed by Gianneschi while he was a faculty member at UC San Diego, where he is now an adjunct faculty. He continued working on the technology at Northwestern.

This work was made possible by research grants from the National Institutes of Health National Heart, Lung, and Blood Institute.

Source: University of California - San Diego

Published May 2025

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